No harm is one of the four bioethics principles that sometimes it and beneficence are defined as one principle. This principle, beside other bioethics principles, is used as an ethics code in modern biotechnologies especially in new achievements in medicine.This principle states that use of modern biotechnologies should not harm to any person even the nature and animals. This principle has a long history in Islam so that we can say it is contemporaneous with it.In Islam it is called la-zarar act that governs all of Jurisprudence as a universal act.Since the jurisprudence supervises on all of interactions and personal and social relationships, naturally it involves this ethical principle that is related to human behavior wit himself / herself and with other congeners.

Medication adverse events are the fourth to sixth cause of death in the United States of America, and the annual deaths due to medication complications and errors in this country are more than of the annual deaths from AIDS, breast cancer and high way accidents. Unsafe medication practices and medication errors are one of the main causes of harm and especially avoidable harm in health care systems worldwide. Globally, the cost of medication errors is estimated at $42 billion annually. The scale and nature of this harms vary among low-, middle-, and high-income countries. Patients living in low-income countries suffer twice as much as patients living in high-income countries. In response to this issue, in 2017, World Health Organization (WHO) introduced “, safe medicine”,as the subject of the third global patient safety challenge. Also, the theme of Patient Safety Day (September 17) last year (2022) was chosen and announced by WHO as “, Medication Without Harm “, and subsequently member countries were requested to increase their activities in this field. The aim of this challenge was to reduce severe avoidable medication-related harm by 50%, globally, in a 5 years’,period. This challenge was formally launched at the Second Global Ministerial Patient Safety Summit in Bonn, Germany on 29 March 2017. WHO calls for urgent action by countries for achieving Medication Without Harm. WHO has introduced four domains for this challenge including patients and the public, health care professionals, medicines and systems and practices of medication. There are also 16 subdomains related to these domains, mainly polypharmacy, high-risk situations and transitions of care. This challenge requires the commitment of health ministers, health system leaders, and stakeholders including educational institutes, drug regulators, researchers, and pharmaceutical companies in order to achieve its main goal in the form of reducing the global amount of severe harm associated with pharmaceutical products. Health care professionals, including pharmacists, can improve medication safety by promoting patient engagement, team-working and a safety culture.

The discussion between general practitioners (GPs) and healthcare delivery organizations necessitates a common language. The presentation of the 4 types of GP’s activities, opens dialogue but can lead to possible misunderstandings between the micro- and macro-level of the healthcare system. This commentary takes 4 examples: costs reduction by P4, priority of beneficence or nonmaleficence, role of evidence-based medicine (EBM) and use of a constructivist model.